Molecular Biology - 中国大学mooc
1. Introduction
Assignment-week 1
1、Please explain the experiment done by Frederick Griffith in 1928 which proved that DNA might be the key genetic material. Please try good academic expression.
2、Please give one example of a biological process at molecular level which shows the smartness of a living organism.
3、Please give an example of a biological process which involves forming and breaking of a weak bond under the physiological conditions present within cells.
2. Genome Structure, Chromatin, and the Nucleosome - I
Assignment-week 2
1、Why are gene densities of eukaryotic genes lower than those of prokaryotic genes?
2、Please describe the composition of human genome.
3、Please describe the process of the generation of a pseudogene we talked in this week class.
3. Genome Structure, Chromatin, and the Nucleosome - II
Assignment-week 3
1、Please describe the composition of a nucleosome.
2、Pleas describe the process of nucleosome assembly.
3、What are the function of N-terminal tail of core histones?
4、Please describe the experiment of digestion of nucleosomal DNA with micrococcal nuclease we talked in this week class.
4. Discussion
Assignment-week 4
1、Please describe the steps of experiment in the following paper. Dintzis H.M. Assembly of the peptide chains of hemoglobin. Proc Natl Acad Sci USA. 1961 Jan 16; 47:247-261.
5. The Structures of DNA and RNA
Assignment-week 5
1、See attachment.
2、What is base flipping? How do you understand it biological relevance?
3、You extracted plasmid A. You would like to know the approximate molecular mass of your plasmid by agarose gel electrophoresis. How would you do?
Assignment-week 1
1、Please explain the experiment done by Frederick Griffith in 1928 which proved that DNA might be the key genetic material. Please try good academic expression.
2、Please give one example of a biological process at molecular level which shows the smartness of a living organism.
3、Please give an example of a biological process which involves forming and breaking of a weak bond under the physiological conditions present within cells.
2. Genome Structure, Chromatin, and the Nucleosome - I
Assignment-week 2
1、Why are gene densities of eukaryotic genes lower than those of prokaryotic genes?
2、Please describe the composition of human genome.
3、Please describe the process of the generation of a pseudogene we talked in this week class.
3. Genome Structure, Chromatin, and the Nucleosome - II
Assignment-week 3
1、Please describe the composition of a nucleosome.
2、Pleas describe the process of nucleosome assembly.
3、What are the function of N-terminal tail of core histones?
4、Please describe the experiment of digestion of nucleosomal DNA with micrococcal nuclease we talked in this week class.
4. Discussion
Assignment-week 4
1、Please describe the steps of experiment in the following paper. Dintzis H.M. Assembly of the peptide chains of hemoglobin. Proc Natl Acad Sci USA. 1961 Jan 16; 47:247-261.
5. The Structures of DNA and RNA
Assignment-week 5
1、See attachment.
2、What is base flipping? How do you understand it biological relevance?
3、You extracted plasmid A. You would like to know the approximate molecular mass of your plasmid by agarose gel electrophoresis. How would you do?